CL-associated papillary conjunctivitis (CLAPC), giant papillary conjunctivitis (GPC)

Contact lens-associated papillary conjunctivitis (CLAPC) is an inflammatory condition which causes characteristic redness and roughness of the upper tarsal conjunctiva (giant papillary conjunctivitis, GPC). Similar symptoms can be seen in response to ocular prosthetics and exposed sutures. This Clinical Management Guideline outlines the aetiology, signs, symptoms and evidence-based recommendations for diagnosing and treating CLAPC. It provides a summary of non-pharmacological management approaches and pharmacological treatment options to manage this condition.

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What is contact lens-associated papillary conjunctivitis?

Contact lens-associated papillary conjunctivitis (CLAPC) is an inflammatory condition affecting the transparent membrane which lines the back of the upper eyelid (tarsal conjunctiva). It can occur in people wearing soft or rigid contact lenses or an ocular prosthesis (artificial eye). People suffering from this condition experience eye irritation, which may lead them to abandon contact lens wear. The eyes are often red and the underside of the upper lid shows minute cobblestone-like swellings called papillae.

How is contact lens-associated papillary conjunctivitis managed?

Treatment for CLAPC initially consists of improving contact lens hygiene, optimising lens fit and replacing lenses more frequently. Eye drops such as anti-histamines or mast cell stabilisers are often required to relieve symptoms and improve clinical signs. In more severe cases it may be necessary to use steroid eye drops for short periods.

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Last updated

CL-associated Papillary Conjunctivitis (CLAPC)
Giant Papillary Conjunctivitis (GPC)
Version 10
Date of search 25.07.23
Date of revision 26.10.23
Date of publication 23.01.24
Date for review 24.07.25
© The College of Optometrists