Retinal vein occlusion

Retinal vein occlusions are blockages of the central retinal vein or one of its branches. They are more common in older people, people with high blood pressure, high cholesterol and those with a history of heart attacks, strokes, diabetes or glaucoma. Patients may notice sudden or gradual painless loss of vision or visual field defect. The two main vision-threatening complications are macular oedema and retinal ischaemia. This Clinical Management Guideline outlines the aetiology, signs and symptoms and evidence-based recommendations for diagnosing retinal vein occlusions. It highlights the need for urgent referral to their GP for medical investigation of systemic disease and baseline assessments required prior to urgent referrals to the hospital eye service.

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What is retinal vein occlusion?

The retina is the area at the back of the eye that receives light and sends pictures of what the eye sees to the brain. Its blood supply is drained by tiny veins. A Retinal Vein Occlusion (RVO) occurs if the blood in one of them clots for some reason. This may affect the main vein (Central Retinal Vein Occlusion, CRVO), one of the two main branches (Hemi-Retinal Vein Occlusion, HRVO) or a smaller branch vein (Branch Retinal Vein Occlusion, BRVO). The patient may notice a sudden painless disturbance of vision.

A RVO is most likely to happen in older people, people with high blood pressure, a history of heart attack or stroke, diabetes, and in glaucoma, as well as in some rarer conditions. 

How is retinal vein occlusion managed?

How it affects the vision in the long term depends on which vessel is affected and whether this starves the retina of oxygen (‘ischaemic’ type) or does not (‘non-ischaemic’ type). The outlook for vision is better in the nonischaemic type. In the ischaemic type, new blood vessels grow into the retina and the iris, which sometimes results in glaucoma. This can be treated by closing the new vessels with the laser.

The main complication of RVO that affects vision is the gathering of fluid at the macula (the most sensitive part of the retina which gives the eye detailed colour vision). Hospital treatment usually includes injections of Anti-Vascular Endothelial Growth Factor (anti-VEGF) or steroids, which has been shown to be safe and effective. In addition, urgent referral to GP may be arranged for medical management and investigation of any underlying condition.

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Last updated

Retinal vein occlusion
Version 3
Date of search 14.06.24
Date of revision 08.08.24
Date of publication 20.09.24
Date for review 13.04.26
© The College of Optometrists