Conjunctival pigmented lesions

Conjunctival pigmented lesions include a number of benign, pre-malignant and malignant melanocytic conditions that are classified according to their cause. These can be congenital or acquired, and include melanosis, naevi and melanomas. They can also be caused by disorders including Addison’s disease and alcaptonuria, and drugs including chlorpromazine and topical epinephrine, but this is rare. This Clinical Management Guideline outlines the aetiology, signs and symptoms and evidence-based recommendations for diagnosing conjunctival pigmented lesions. It provides recommendations for non-pharmacological management, and outlines when referral is required.

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What are conjunctival pigmented lesions?

The conjunctiva (the transparent skin over the white of the eye) sometimes develops brown discolouration. This is classified according to the cause:

Hypermelanosis: melanocytes (the cells of the body that produce the dark pigment melanin) go into overproduction. This may be a normal characteristic , or it may be caused by disease elsewhere in the body.

Primary Acquired Melanosis: unusually large numbers of melanocytes develop. This is rare in dark-skinned races and tends to affect older white-skinned people.

Congenital Melanocytosis: similar, except present from birth.

A Naevus, that is a brown spot on the conjunctiva, may be present from birth or may arise later. This is the commonest of all the conjunctival pigmented lesions. Usually it does not grow or spread.

Sometimes, a naevus changes into an Invasive Melanoma, also known as a Malignant Melanoma, which can spread to other parts of the body. This particularly affects people with fair complexions and is seen only very rarely in dark-skinned people.

There are also some uncommon generalised diseases that may produce discolouration of the conjunctiva. Some prescription drugs may also cause a similar effect.

How are conjunctival pigmented lesions managed?

Depending on the nature of the pigmented lesion, optometrists may monitor the condition themselves, or refer to an ophthalmologist routinely or urgently. Mild ethnic melanosis does not need to be referred.

The ophthalmologist will carry out tests to identify which condition the patient has. Melanoma is usually treated with surgery and additional drug therapy. Careful follow-up is required due to high rates of recurrence.

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Last updated

Conjunctival pigmented lesions
Version 10
Date of search 30.09.22
Date of revision 20.12.22
Date of publication 09.01.23
Date for review 29.09.24
© The College of Optometrists